Article
Mutations of the human beta 2-adrenergic receptor that impair coupling to Gs interfere with receptor down-regulation but not sequestration.
Molecular pharmacology - 1 Feb 1991
Campbell P T, Hnatowich M, O'Dowd B F, Caron M G, Lefkowitz R J, Hausdorff W P
Abstract excerpt
The integrity of coupling of the beta 2-adrenergic receptor (beta 2AR) to its guanine nucleotide-binding protein, Gs, and phosphorylation events on the receptor molecule have been proposed to be important determinants in the processes of receptor sequestration and down-regulation. However, little is known about the molecular mechanisms underlying these processes, and the regions of the receptor molecule that...
Topics
- Amino Acid Sequence
- Animals
- Cricetinae
- Cricetulus
- Down-Regulation
- Fibroblasts
- GTP-Binding Proteins
- Humans
- Molecular Sequence Data
- Mutation
- Phosphorylation