TAP2 association with insulin-dependent diabetes mellitus is secondary to HLA-DQB1.

doi:10.1016/0198-8859(94)00124-9

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Article

TAP2 association with insulin-dependent diabetes mellitus is secondary to HLA-DQB1.

Human immunology - 1 May 1995

Jackson D G, Capra J D

Abstract excerpt

IDDM is known to be associated with genes of HLA complex, particularly alleles of HLA-DQ. The 40-kb TAP gene complex is located approximately 150 kb centrometric to the DQB1 locus. The TAP1-TAP2 protein heterodimer is required for normal expression levels of class I, molecules on the surface of c...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 3
ATP-Binding Cassette Transporters
Alleles
Amino Acid Sequence
Base Sequence
Child
Diabetes Mellitus, Type 1
Female
Genotype
HLA-DQ Antigens
HLA-DQ beta-Chains
Humans
Male
Molecular Sequence Data

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