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Article

TAP2 association with insulin-dependent diabetes mellitus is secondary to HLA-DQB1.

Human immunology - 1 May 1995

Jackson D G, Capra J D

Abstract excerpt

IDDM is known to be associated with genes of HLA complex, particularly alleles of HLA-DQ. The 40-kb TAP gene complex is located approximately 150 kb centrometric to the DQB1 locus. The TAP1-TAP2 protein heterodimer is required for normal expression levels of class I, molecules on the surface of cells. While present evidence implicates HLA-DQ as the major susceptibility locus in IDDM, as class I expression...

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Source

Identifiers

PMID: 7558930
DOI: 10.1016/0198-8859(94)00124-9

Genes

TAP2
TAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TAP2 association with insulin-dependent diabetes mellitus is secondary to HLA-DQB1.PMID 7558930Read ↗

Family study of linkage disequilibrium between TAP2 transporter and HLA class II genes. Absence of TAP2 contribution to association with insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Insulin-dependent diabetes mellitus and the major histocompatibility complex peptide transporters TAP1 and TAP2: no association in a population with a high disease incidence.Semantic proximity Read ↗

Linkage disequilibrium between TAP2 variants and HLA class II alleles; no primary association between TAP2 variants and insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Susceptibility to insulin-dependent diabetes mellitus and short cytoplasmic ATP-binding domain TAP2*01 alleles.Semantic proximity Read ↗

Analysis of TAP2 polymorphisms in Finnish individuals with type I diabetes.Semantic proximity Read ↗

Protection from insulin-dependent diabetes mellitus is linked to a peptide transporter gene.Semantic proximity Read ↗

TAP1 and TAP2 transporter genes and predisposition to insulin dependent diabetes mellitus.Semantic proximity Read ↗

Associations between alleles of the major histocompatibility complex-encoded ABC transporter gene TAP2, HLA class II alleles, and celiac disease susceptibility.Semantic proximity Read ↗

TAP1 alleles in insulin-dependent diabetes mellitus: a newly defined centromeric boundary of disease susceptibility.Semantic proximity Read ↗

Major histocompatibility complex-encoded antigen processing gene polymorphism in IDDM.Semantic proximity Read ↗

Polymorphisms of TAP1 and TAP2 genes in German patients with type 1 diabetes mellitus.Semantic proximity Read ↗

Lack of association of the transporter associated with antigen processing with Japanese insulin-dependent diabetes mellitus.Semantic proximity Read ↗

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