Article
Family study of linkage disequilibrium between TAP2 transporter and HLA class II genes. Absence of TAP2 contribution to association with insulin-dependent diabetes mellitus.
Human immunology - 1 Oct 1995
Caillat-Zucman S, Daniel S, Djilali-Saiah I, Timsit J, Garchon H J, Boitard C, Bach J F
Abstract excerpt
The polymorphic TAP1 and TAP2 genes encode a transporter protein required for delivery of cytosolic peptides to class I molecules in the endoplasmic reticulum. Associations have been observed between TAP2 alleles and predisposition to autoimmune diseases such as IDDM but their interpretation has...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 3
- ATP-Binding Cassette Transporters
- Alleles
- Diabetes Mellitus, Type 1
- Disease Susceptibility
- Genes, MHC Class II
- Genetic Predisposition to Disease
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- HLA-DR Antigens
- HLA-DRB1 Chains
- Haplotypes
- Humans