Article
Susceptibility to insulin-dependent diabetes mellitus and short cytoplasmic ATP-binding domain TAP2*01 alleles.
Tissue antigens - 1 Sept 1994
Martinez-Laso J, Martin-Villa J M, Alvarez M, Martinez-Quiles N, Lledo G, Arnaiz-Villena A
Abstract excerpt
TAP2 genes are placed within the HLA complex, have limited genetic variability and encode two main groups of peptide transporter proteins, the so-called TAP2*01 alleles, with a short ATP-binding domain, and the TAP2*0201 allele with a long domain. These transporters carry antigenic peptides from cytoplasm across the endoplasmic reticulum membrane to release them into nascent HLA class I molecules, which will then...
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