Article
Susceptibility to insulin-dependent diabetes mellitus and short cytoplasmic ATP-binding domain TAP2*01 alleles.
Tissue antigens - 1 Sept 1994
Martinez-Laso J, Martin-Villa J M, Alvarez M, Martinez-Quiles N, Lledo G, Arnaiz-Villena A
Abstract excerpt
TAP2 genes are placed within the HLA complex, have limited genetic variability and encode two main groups of peptide transporter proteins, the so-called TAP2*01 alleles, with a short ATP-binding domain, and the TAP2*0201 allele with a long domain. These transporters carry antigenic peptides from cytoplasm across the endoplasmic reticulum membrane to release them into nascent HLA class I molecules, which will then...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 3
- ATP-Binding Cassette Transporters
- Alleles
- Amino Acid Sequence
- Base Sequence
- Diabetes Mellitus, Type 1
- Genetic Predisposition to Disease
- Humans
- Molecular Sequence Data
- Oligonucleotide Probes