Article
Linkage disequilibrium between TAP2 variants and HLA class II alleles; no primary association between TAP2 variants and insulin-dependent diabetes mellitus.
European journal of immunology - 1 May 1993
Rønningen K S, Undlien D E, Ploski R, Maouni N, Konrad R J, Jensen E, Hornes E, Reijonen H, Colonna M, Monos D S
Abstract excerpt
The TAP1 and TAP2 genes, located in the HLA class II region, encode subunits of a peptide transporter. Both genes display limited genetic variability; four different nucleotide substitutions have been found in the TAP2 gene. Here studies on linkage disequilibrium between TAP2 variants and HLA cla...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 3
- ATP-Binding Cassette Transporters
- Alleles
- Base Sequence
- Biological Transport
- Carrier Proteins
- Diabetes Mellitus, Type 1
- Genes, MHC Class II
- Genetic Variation
- HLA-DP Antigens