Article
Linkage disequilibrium between TAP2 variants and HLA class II alleles; no primary association between TAP2 variants and insulin-dependent diabetes mellitus.
European journal of immunology - 1 May 1993
Rønningen K S, Undlien D E, Ploski R, Maouni N, Konrad R J, Jensen E, Hornes E, Reijonen H, Colonna M, Monos D S
Abstract excerpt
The TAP1 and TAP2 genes, located in the HLA class II region, encode subunits of a peptide transporter. Both genes display limited genetic variability; four different nucleotide substitutions have been found in the TAP2 gene. Here studies on linkage disequilibrium between TAP2 variants and HLA class II alleles are reported, in an attempt to evaluate whether TAP2 variants are associated with insulin-dependent...
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