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Article

Lack of association of the transporter associated with antigen processing with Japanese insulin-dependent diabetes mellitus.

Metabolism: clinical and experimental - 1 Aug 1994

Nakanishi K, Kobayashi T, Murase T, Kosaka K

Abstract excerpt

The transporter associated with antigen processing (TAP) encoded in the major histocompatibility complex (MHC) class II region is a molecule required for endogenous antigen processing. We have typed TAP polymorphism in 95 Japanese patients with insulin-dependent diabetes mellitus (DDM) and 75 normal controls. Amino acid substitutions at positions 333 and 637 of TAP1 and at positions 379, 665, and 687 of TAP2 were...

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Source

Identifiers

PMID: 8052140
DOI: 10.1016/0026-0495(94)90182-1

Genes

TAP1
TAP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lack of association of the transporter associated with antigen processing with Japanese insulin-dependent diabetes mellitus.PMID 8052140Read ↗

Absence of association of TAP and LMP genes with type 1 (insulin-dependent) diabetes mellitus.Semantic proximity Read ↗

Insulin-dependent diabetes mellitus and the major histocompatibility complex peptide transporters TAP1 and TAP2: no association in a population with a high disease incidence.Semantic proximity Read ↗

Lack of primary association between transporter associated with antigen processing genes and atopic dermatitis.Semantic proximity Read ↗

Polymorphisms of transporter associated with antigen processing genes in atopic dermatitis.Semantic proximity Read ↗

TAP2 association with insulin-dependent diabetes mellitus is secondary to HLA-DQB1.Semantic proximity Read ↗

Protection from insulin-dependent diabetes mellitus is linked to a peptide transporter gene.Semantic proximity Read ↗

Polymorphisms of TAP1 and TAP2 genes in German patients with type 1 diabetes mellitus.Semantic proximity Read ↗

Evaluation of TAP1 polymorphisms with insulin dependent diabetes mellitus in Finnish diabetic patients. The Childhood Diabetes in Finland (DiMe) Study Group.Semantic proximity Read ↗

Major histocompatibility complex-encoded antigen processing gene polymorphism in IDDM.Semantic proximity Read ↗

Analysis of HLA class II and TAP alleles in Japanese patients with psoriasis vulgaris.Semantic proximity Read ↗

Family study of linkage disequilibrium between TAP2 transporter and HLA class II genes. Absence of TAP2 contribution to association with insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Susceptibility to insulin-dependent diabetes mellitus and short cytoplasmic ATP-binding domain TAP2*01 alleles.Semantic proximity Read ↗

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