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Article

Lack of association of the transporter associated with antigen processing with Japanese insulin-dependent diabetes mellitus.

Metabolism: clinical and experimental - 1 Aug 1994

Nakanishi K, Kobayashi T, Murase T, Kosaka K

Abstract excerpt

The transporter associated with antigen processing (TAP) encoded in the major histocompatibility complex (MHC) class II region is a molecule required for endogenous antigen processing. We have typed TAP polymorphism in 95 Japanese patients with insulin-dependent diabetes mellitus (DDM) and 75 normal controls. Amino acid substitutions at positions 333 and 637 of TAP1 and at positions 379, 665, and 687 of TAP2 were...

Topics

Adolescent
Adult
Alleles
Antigen Presentation
Carrier Proteins
Child
Diabetes Mellitus, Type 1
Female
Genes, MHC Class II
HLA-DQ Antigens
Histocompatibility Antigens Class II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Japan

Male

Middle Aged

Polymorphism, Genetic

Source

Identifiers

PMID: 8052140
DOI: 10.1016/0026-0495(94)90182-1

Genes

TAP1
TAP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8052140-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Lack of association of the transporter associated with antigen processing with Japanese insulin-dependent diabetes mellitus.PMID 8052140Read ↗

Absence of association of TAP and LMP genes with type 1 (insulin-dependent) diabetes mellitus.Semantic proximity Read ↗

Insulin-dependent diabetes mellitus and the major histocompatibility complex peptide transporters TAP1 and TAP2: no association in a population with a high disease incidence.Semantic proximity Read ↗

Lack of primary association between transporter associated with antigen processing genes and atopic dermatitis.Semantic proximity Read ↗

Polymorphisms of transporter associated with antigen processing genes in atopic dermatitis.Semantic proximity Read ↗

TAP2 association with insulin-dependent diabetes mellitus is secondary to HLA-DQB1.Semantic proximity Read ↗

Protection from insulin-dependent diabetes mellitus is linked to a peptide transporter gene.Semantic proximity Read ↗

Polymorphisms of TAP1 and TAP2 genes in German patients with type 1 diabetes mellitus.Semantic proximity Read ↗

Evaluation of TAP1 polymorphisms with insulin dependent diabetes mellitus in Finnish diabetic patients. The Childhood Diabetes in Finland (DiMe) Study Group.Semantic proximity Read ↗

Major histocompatibility complex-encoded antigen processing gene polymorphism in IDDM.Semantic proximity Read ↗

Analysis of HLA class II and TAP alleles in Japanese patients with psoriasis vulgaris.Semantic proximity Read ↗

Family study of linkage disequilibrium between TAP2 transporter and HLA class II genes. Absence of TAP2 contribution to association with insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Susceptibility to insulin-dependent diabetes mellitus and short cytoplasmic ATP-binding domain TAP2*01 alleles.Semantic proximity Read ↗

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