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Article

Protection from insulin-dependent diabetes mellitus is linked to a peptide transporter gene.

European journal of immunology - 1 Aug 1993

Caillat-Zucman S, Bertin E, Timsit J, Boitard C, Assan R, Bach J F

Abstract excerpt

HLA class II association with insulin-dependent diabetes mellitus (IDDM) is well established but is still difficult to map to a particular locus. Polymorphism of the genes coding for transporter associated with antigen processing (TAP1 and TAP2), and located in the HLA class II region, was studied in 167 IDDM patients (116 adult-onset and 51 childhood-onset patients) and 98 normal controls using oligotyping after...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 8344340
DOI: 10.1002/eji.1830230808

Genes

TAP2
TAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Protection from insulin-dependent diabetes mellitus is linked to a peptide transporter gene.PMID 8344340Read ↗

TAP1 and TAP2 transporter genes and predisposition to insulin dependent diabetes mellitus.Semantic proximity Read ↗

TAP2 association with insulin-dependent diabetes mellitus is secondary to HLA-DQB1.Semantic proximity Read ↗

Family study of linkage disequilibrium between TAP2 transporter and HLA class II genes. Absence of TAP2 contribution to association with insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Insulin-dependent diabetes mellitus and the major histocompatibility complex peptide transporters TAP1 and TAP2: no association in a population with a high disease incidence.Semantic proximity Read ↗

Susceptibility to insulin-dependent diabetes mellitus and short cytoplasmic ATP-binding domain TAP2*01 alleles.Semantic proximity Read ↗

Polymorphisms of TAP1 and TAP2 genes in German patients with type 1 diabetes mellitus.Semantic proximity Read ↗

Linkage disequilibrium between TAP2 variants and HLA class II alleles; no primary association between TAP2 variants and insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Analysis of TAP2 polymorphisms in Finnish individuals with type I diabetes.Semantic proximity Read ↗

Genetic heterogeneity between type 1a and type 1b insulin-dependent diabetes mellitus: HLA class II and TAP gene analysis.Semantic proximity Read ↗

Evaluation of TAP1 polymorphisms with insulin dependent diabetes mellitus in Finnish diabetic patients. The Childhood Diabetes in Finland (DiMe) Study Group.Semantic proximity Read ↗

Associations between alleles of the major histocompatibility complex-encoded ABC transporter gene TAP2, HLA class II alleles, and celiac disease susceptibility.Semantic proximity Read ↗

Lack of association of the transporter associated with antigen processing with Japanese insulin-dependent diabetes mellitus.Semantic proximity Read ↗

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