Article
Polymorphisms of TAP1 and TAP2 genes in German patients with type 1 diabetes mellitus.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics - 1 Jun 1997
Rau H, Nicolay A, Donner H, Usadel K H, Badenhoop K
Abstract excerpt
Type 1 diabetes mellitus (IDDM) is an autoimmune disorder in which the alleles HLA DQA1*0501-DQB1*0201 and DQA1*0301-DQB1*0302 confer strong susceptibility. The genes for transporters associated with antigen processing (TAP1 and TAP2) are located near HLA DQ and display only a limited degree of p...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 2
- ATP Binding Cassette Transporter, Subfamily B, Member 3
- ATP-Binding Cassette Transporters
- Alleles
- DNA
- DNA Probes, HLA
- Diabetes Mellitus, Type 1
- Gene Frequency
- Germany
- Humans
- Linkage Disequilibrium
- Major Histocompatibility Complex
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Polymorphism, Single-Stranded Conformational
- Regression Analysis
