Article
Polymorphisms of TAP1 and TAP2 genes in German patients with type 1 diabetes mellitus.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics - 1 Jun 1997
Rau H, Nicolay A, Donner H, Usadel K H, Badenhoop K
Abstract excerpt
Type 1 diabetes mellitus (IDDM) is an autoimmune disorder in which the alleles HLA DQA1*0501-DQB1*0201 and DQA1*0301-DQB1*0302 confer strong susceptibility. The genes for transporters associated with antigen processing (TAP1 and TAP2) are located near HLA DQ and display only a limited degree of polymorphism. Since polymorphisms of TAP might influence susceptibility to IDDM possibly by selection of different...
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