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Article

TAP1 and TAP2 transporter genes and predisposition to insulin dependent diabetes mellitus.

Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie - 1 Jan 1992

Caillat-Zucman S, Bertin E, Timsit J, Boitard C, Assan R, Bach J F

Abstract excerpt

Genetic control of insulin dependent diabetes mellitus (IDDM) is mainly dependent on HLA genes in the major histocompatibility complex (MHC). The participation of TAP1 and TAP2 genes, located in the MHC region and coding for antigenic peptide transporters, was investigated in 116 IDDM patients and 98 normal controls using oligotyping after DNA amplification. The TAP2-B allele had a dominant protective effect,...

Topics

Adult
Alleles
Diabetes Mellitus, Type 1
Haplotypes
Humans
Major Histocompatibility Complex

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1300236

Genes

TAP2
TAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1300236-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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TAP1 and TAP2 transporter genes and predisposition to insulin dependent diabetes mellitus.PMID 1300236Read ↗

Protection from insulin-dependent diabetes mellitus is linked to a peptide transporter gene.Semantic proximity Read ↗

Polymorphisms of TAP1 and TAP2 genes in German patients with type 1 diabetes mellitus.Semantic proximity Read ↗

Susceptibility to insulin-dependent diabetes mellitus and short cytoplasmic ATP-binding domain TAP2*01 alleles.Semantic proximity Read ↗

TAP2 association with insulin-dependent diabetes mellitus is secondary to HLA-DQB1.Semantic proximity Read ↗

Family study of linkage disequilibrium between TAP2 transporter and HLA class II genes. Absence of TAP2 contribution to association with insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Insulin-dependent diabetes mellitus and the major histocompatibility complex peptide transporters TAP1 and TAP2: no association in a population with a high disease incidence.Semantic proximity Read ↗

Evaluation of TAP1 polymorphisms with insulin dependent diabetes mellitus in Finnish diabetic patients. The Childhood Diabetes in Finland (DiMe) Study Group.Semantic proximity Read ↗

Analysis of TAP2 polymorphisms in Finnish individuals with type I diabetes.Semantic proximity Read ↗

Linkage disequilibrium between TAP2 variants and HLA class II alleles; no primary association between TAP2 variants and insulin-dependent diabetes mellitus.Semantic proximity Read ↗

The role of MHC class II genes in susceptibility to insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Genetic heterogeneity between type 1a and type 1b insulin-dependent diabetes mellitus: HLA class II and TAP gene analysis.Semantic proximity Read ↗

Associations between alleles of the major histocompatibility complex-encoded ABC transporter gene TAP2, HLA class II alleles, and celiac disease susceptibility.Semantic proximity Read ↗

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