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Article

Genotoxic effects of p-aminophenol in Chinese hamster ovary and mouse lymphoma cells: results of a multiple endpoint test.

Environmental and molecular mutagenesis - 1 Jan 1995

Majeska J B, Holden H E

Abstract excerpt

p-Aminophenol (PAP), a metabolite of aniline and acetaminophen, has been reported to be mutagenic in the L5178Y mouse lymphoma assay, but not in the CHO/HGPRT assay. In the present study, the effects of PAP in these two cells lines were examined to determine if the difference in activity is related to an intrinsic difference in the cell lines. CHO and L5178Y tk +/- mouse lymphoma cells were treated with PAP for 4...

Topics

Aminophenols
Animals
CHO Cells
Cell Survival
Chromosome Aberrations
Cricetinae
Cricetulus
DNA, Single-Stranded
Dose-Response Relationship, Drug
Electrophoresis
Genes, araC

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hypoxanthine Phosphoribosyltransferase

Lymphoma

Mice

Mutation

Tumor Cells, Cultured

Source

Identifiers

PMID: 7556113
DOI: 10.1002/em.2850260210

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7556113-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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