Article
Relationships between p53 status, apoptosis and induction of micronuclei in different human and mouse cell lines in vitro: Implications for improving existing assays.
Mutation research. Genetic toxicology and environmental mutagenesis - 1 Aug 2015
Whitwell James, Smith Robert, Jenner Karen, Lyon Heather, Wood Deborah, Clements Julie, Aschcroft-Hawley Kelly, Gollapudi Bhaskar, Kirkland David, Lorge Elisabeth, Pfuhler Stefan, Tanir Jennifer Y, Thybaud Veronique
Abstract excerpt
Accumulated evidence has shown that in vitro mammalian cell genotoxicity assays produce high frequencies of "misleading" positive results, i.e. predicted hazard is not confirmed in in vivo and/or carcinogenicity studies [1], raising the question of relevance to human risk assessment. A recent study of micronucleus (MN) induction [2] showed that commonly used p53-deficient rodent cell lines (CHL, CHO and V79) gave...
Topics
- Acrylates
- Animals
- Apoptosis
- Cell Line
- Cell Line, Tumor
- Cell Survival
- Chlorophenols
- Curcumin
- Cytochalasin B
- DNA Damage