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Article

Gene mutation assay of acrolein in the CHO/HGPRT test system.

Journal of applied toxicology : JAT - 1 Apr 1991

Parent R A, Caravello H E, Harbell J W

Abstract excerpt

The mutagenic potential of acrolein has been studied with a wide range of in vitro and in vivo genetic toxicity assays. The data often have been conflicting, especially with the Ames assay. This study was undertaken to assess the mutagenic potential of acrolein using the CHO/HGPRT assay, both with and without metabolic activation. This assay system was chosen because it provides eukaryotic DNA as the target and...

Topics

Acrolein
Animals
Cell Line
Genetic Linkage
Hypoxanthine Phosphoribosyltransferase
Male
Mutagenicity Tests
Mutagens
Phenotype
Rats
Rats, Inbred Strains
X Chromosome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 2061556
DOI: 10.1002/jat.2550110204

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2061556-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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