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Can the L5178Y Tk+/- mouse lymphoma assay detect epigenetic silencing?

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 1 Sept 2013

Cheng Tsu-Fan, Patton Geoffrey W, Muldoon-Jacobs Kristi

Abstract excerpt

The mouse lymphoma L5178Y Tk(+/-) assay is broadly used in toxicology to assess genotoxicity because of its known sensitivity to genotoxicants that act through a variety of mechanisms, which may include epigenetic DNA methylation. This brief article highlights the studies that have contributed to this conjecture and suggests an addition to the experimental design that could identify if the test substance is a...

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PMID: 23778052
DOI: 10.1016/j.fct.2013.06.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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