Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of mutations induced by replication of UV-damaged plasmid DNA in HeLa cell extracts.

Environmental and molecular mutagenesis - 1 Jan 1995

Carty M P, el-Saleh S, Zernik-Kobak M, Dixon K

Abstract excerpt

We have used an SV40-based shuttle vector, pZ189, to investigate the capacity of HeLa cell extracts to reproduce the in vivo process of mutation fixation. We showed previously that when UV-irradiated pZ189 is replicated in these extracts, bypass of UV photoproducts occurs, resulting in base substitution mutations in the supF gene of the vector. Here we report the DNA sequence characterization of a collection of...

Topics

Base Sequence
Binding Sites
Cell Extracts
Cells, Cultured
DNA Damage
DNA Replication
Escherichia coli
Genetic Vectors
HeLa Cells
Humans
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Plasmids

Pyrimidines

Transformation, Bacterial

Ultraviolet Rays

Source

Identifiers

PMID: 7556110
DOI: 10.1002/em.2850260207

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7556110-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of mutations induced by replication of UV-damaged plasmid DNA in HeLa cell extracts.PMID 7556110Read ↗

XPA protein alters the specificity of ultraviolet light-induced mutagenesis in vitro.Semantic proximity Read ↗

DNA sequence of mutations induced in cells by herpes simplex virus type-1.Semantic proximity Read ↗

Evidence of the involvement of p53 in gamma-radiation-induced DNA repair in human lymphoblasts.Semantic proximity Read ↗

Mutations induced by ionizing radiation in a plasmid replicated in human cells. I. Similar, nonrandom distribution of mutations in unirradiated and X-irradiated DNA.Semantic proximity Read ↗

Similarity in the molecular profile of mutations induced by UV light in shuttle vector plasmids propagated in mouse and human cells.Semantic proximity Read ↗

Evidence for a Rad18-independent frameshift mutagenesis pathway in human cell-free extracts.Semantic proximity Read ↗

Mutations induced by ionizing radiation in a plasmid replicated in human cells. II. Sequence analysis of alpha-particle-induced point mutations.Semantic proximity Read ↗

Dependence of the mutation spectrum in a shuttle plasmid replicated in human lymphoblasts on dose of gamma radiation.Semantic proximity Read ↗

Xeroderma pigmentosum variant cells are less likely than normal cells to incorporate dAMP opposite photoproducts during replication of UV-irradiated plasmids.Semantic proximity Read ↗

Analysis of N-methyl-N-nitrosourea-induced mutations in a shuttle vector plasmid propagated in mouse O6-methylguanine-DNA methyltransferase-deficient cells in comparison with proficient cells.Semantic proximity Read ↗

Abnormal, error-prone bypass of photoproducts by xeroderma pigmentosum variant cell extracts results in extreme strand bias for the kinds of mutations induced by UV light.Semantic proximity Read ↗

Gene targeted DNA double-strand break induction by (125)I-labeled triplex-forming oligonucleotides is highly mutagenic following repair in human cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.