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Article

Evidence for a Rad18-independent frameshift mutagenesis pathway in human cell-free extracts.

PloS one - 1 Jan 2012

Janel-Bintz Régine, Wagner Jérôme, Haracska Lajos, Mah-Becherel Marcia Chia Miao, Bichara Marc, Fuchs Robert P, Cordonnier Agnès M

Abstract excerpt

Bypass of replication blocks by specialized DNA polymerases is crucial for cell survival but may promote mutagenesis and genome instability. To gain insight into mutagenic sub-pathways that coexist in mammalian cells, we examined N-2-acetylaminofluorene (AAF)-induced frameshift mutagenesis by means of SV40-based shuttle vectors containing a single adduct. We found that in mammalian cells, as previously observed...

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PMID: 22558303
DOI: 10.1371/journal.pone.0036004
PMCID: PMC3338768

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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