Article
Microsatellite instability is associated with the histological features of the tumor in nonfamilial colorectal cancer.
Cancer research - 1 Dec 1996
Risio M, Reato G, di Celle P F, Fizzotti M, Rossini F P, Foà R
Abstract excerpt
Replication errors (RERs) at microsatellite loci were examined in 46 specimens of nonfamilial colorectal cancer. Somatic microsatellite alterations in at least two genetic loci, D11S904, D13S175, D2S123, and D10S197, consistent with a RER(+) phenotype were found in four cases (8.7%). Six additional cases (13%) showed alterations at a single locus. Mucinous differentiation was observed in 3 of 4 (75%)...
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