[Mutation of the mismatch repair genes for carcinogenesis of sporadic colorectal cancers with RER-positive phenotype].

Article

[Mutation of the mismatch repair genes for carcinogenesis of sporadic colorectal cancers with RER-positive phenotype].

Nihon rinsho. Japanese journal of clinical medicine - 1 Apr 1996

Sasaki S, Nakamura Y

Abstract excerpt

Genetic instability, monitored by (a) replication error, is a feature of many hereditary and sporadic colorectal cancers. When such tumors are familial, the genetic instability is thought to be triggered by inherited mutations in DNA-mismatch repair genes but the mechanism by which sporadic tumor...

Topics

Colonic Neoplasms
DNA Repair
DNA Replication
Humans
Mutation
Phenotype

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