Replication errors in benign and malignant tumors from hereditary nonpolyposis colorectal cancer patients.

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Article

Replication errors in benign and malignant tumors from hereditary nonpolyposis colorectal cancer patients.

Cancer research - 1 Apr 1994

Aaltonen L A, Peltomäki P, Mecklin J P, Järvinen H, Jass J R, Green J S, Lynch H T, Watson P, Tallqvist G, Juhola M

Abstract excerpt

A replication error (RER) phenotype has been documented both in sporadic colorectal tumors and in tumors from patients with hereditary nonpolyposis colorectal cancer (HNPCC). In the current study 8 of 49 (16%) sporadic colorectal cancers (CRCs) and 25 of 29 (86%) CRCs from HNPCC patients were fou...

Topics

Adenoma
Chromosomes, Human, Pair 2
Colorectal Neoplasms
Colorectal Neoplasms, Hereditary Nonpolyposis
DNA Repair
DNA Replication
Family
Gene Frequency
Humans
Middle Aged
Mutation

Source

Open in PubMed

Identifiers

PMID: 8137274

Genes

MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8137274-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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