Article
Decreased expression and rare somatic mutation of the CIP1/WAF1 gene in human hepatocellular carcinoma.
Cancer letters - 1 Jan 1997
Furutani M, Arii S, Tanaka H, Mise M, Niwano M, Harada T, Higashitsuji H, Imamura M, Fujita J
Abstract excerpt
CIP1/WAF1, a critical downstream effector of tumor suppressor p53, encodes a cyclin-dependent kinase inhibitor. By Northern blot analysis, the CIP1/WAF1 mRNA level in the tumor was significantly lower than that in the corresponding normal liver from 19 Japanese patients with hepatocellular carcin...
Topics
- Adult
- Aged
- Carcinoma, Hepatocellular
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- Down-Regulation
- Female
- Humans
- Liver Neoplasms
- Male
- Middle Aged
- Mutation
- Neoplasm Proteins
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- RNA, Messenger