Hoxc-9 mutant mice show anterior transformation of the vertebrae and malformation of the sternum and ribs.

doi:10.1016/0925-4773(95)00371-1

Back to search

Article

Hoxc-9 mutant mice show anterior transformation of the vertebrae and malformation of the sternum and ribs.

Mechanisms of development - 1 Jun 1995

Suemori H, Takahashi N, Noguchi S

Abstract excerpt

To clarify the function of the Hoxc-9 gene, we have introduced a mutation into the Hoxc-9 locus by gene targeting. Skeletal analysis of homozygotes revealed that anterior homeotic transformation occurred from the 10th thoracic vertebrae to the first lumbar vertebra. Bending and fusion of the ribs...

Topics

Animals
Base Sequence
DNA Primers
Female
Genes, Homeobox
Gestational Age
Growth Disorders
Heterozygote
Homozygote
Male
Mice
Mice, Inbred A
Mice, Inbred C57BL
Mice, Mutant Strains
Molecular Sequence Data
Mutation
Pregnancy
Ribs

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.