Article
Axial skeleton homeosis and forelimb malformations in Hoxd-11 mutant mice.
Proceedings of the National Academy of Sciences of the United States of America - 3 Jan 1995
Favier B, Le Meur M, Chambon P, Dollé P
Abstract excerpt
The Hoxd-11 gene was disrupted by homologous recombination in embryonic stem cells. We found that Hoxd-11-/- mutant mice are viable and display homeotic transformations of their sacral vertebrae, while their forelimbs present abnormalities of some metacarpals and of the first row of carpal bones....
Topics
- Animals
- Bone and Bones
- Cosmids
- Exons
- Forelimb
- Genes, Homeobox
- Mice
- Mice, Mutant Strains
- Phenotype
- Recombination, Genetic
- Restriction Mapping
- Spinal Cord