Homeosis in the mouse induced by a null mutation in the Hox-3.1 gene.

doi:10.1016/0092-8674(92)90406-3

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Article

Homeosis in the mouse induced by a null mutation in the Hox-3.1 gene.

Cell - 17 Apr 1992

Le Mouellic H, Lallemand Y, Brûlet P

Abstract excerpt

We have replaced the Hox-3.1 coding sequence with the E. coli lacZ gene by means of homologous recombination in embryonic stem cells and thus produced null mutant mice. Homozygous mice were born alive, but most of them died within a few days. In the trunk region of homozygotes, several skeletal segments were transformed into the likeness of more anterior ones, as observed in Drosophila with loss-of-function...

Topics

Animals
Base Sequence
Cell Line
Chimera
DNA-Binding Proteins
Gene Expression Regulation
Genes, Homeobox
Homeodomain Proteins
Lac Operon
Mice
Mice, Inbred C57BL
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Morphogenesis

Mutation

Ribs

Transfection

Transformation, Genetic

beta-Galactosidase

Source

Open in PubMed

Identifiers

PMID: 1348969
DOI: 10.1016/0092-8674(92)90406-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1348969-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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