Article
Hox10 and Hox11 genes are required to globally pattern the mammalian skeleton.
Science (New York, N.Y.) - 18 Jul 2003
Wellik Deneen M, Capecchi Mario R
Abstract excerpt
Mice in which all members of the Hox10 or Hox11 paralogous group are disrupted provide evidence that these Hox genes are involved in global patterning of the axial and appendicular skeleton. In the absence of Hox10 function, no lumbar vertebrae are formed. Instead, ribs project from all posterior vertebrae, extending caudally from the last thoracic vertebrae to beyond the sacral region. In the absence of Hox11...
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