Article
Somatic mutation of the tuberous sclerosis (Tsc2) tumor suppressor gene in chemically induced rat renal carcinoma cell.
The Journal of urology - 1 Jul 1997
Urakami S, Tokuzen R, Tsuda H, Igawa M, Hino O
Abstract excerpt
PURPOSE: von Hippel-Lindau (VHL) gene mutations are detected in noninherited, sporadic human renal cell carcinomas (RCs) at a high frequency. We recently identified a germline mutation in the rat homologue of the human tuberous sclerosis (TSC2) predisposing RC gene in the Eker rat model, and in t...
Topics
- Animals
- Carcinogens
- Carcinoma, Renal Cell
- Diethylnitrosamine
- Genes, Tumor Suppressor
- Kidney Neoplasms
- Ligases
- Male
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Proteins
- Rats
- Rats, Wistar
- Repressor Proteins
- Tuberous Sclerosis Complex 2 Protein
- Tumor Suppressor Proteins
- Ubiquitin-Protein Ligases