Article
Hypertension in mice lacking the gene for endothelial nitric oxide synthase.
Nature - 21 Sept 1995
Huang P L, Huang Z, Mashimo H, Bloch K D, Moskowitz M A, Bevan J A, Fishman M C
Abstract excerpt
Nitric oxide (NO), a potent vasodilator produced by endothelial cells, is thought to be the endothelium-dependent relaxing factor (EDRF) which mediates vascular relaxation in response to acetylcholine, bradykinin and substance P in many vascular beds. NO has been implicated in the regulation of blood pressure and regional blood flow, and also affects vascular smooth-muscle proliferation and inhibits platelet...
Topics
- Amino Acid Oxidoreductases
- Animals
- Aorta
- Arginine
- Blood Pressure
- Endothelium, Vascular
- Homeostasis
- Hypertension
- In Vitro Techniques
- Mice
- Mutation
- Nitric Oxide Synthase