Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypertension in mice lacking the gene for endothelial nitric oxide synthase.

Nature - 21 Sept 1995

Huang P L, Huang Z, Mashimo H, Bloch K D, Moskowitz M A, Bevan J A, Fishman M C

Abstract excerpt

Nitric oxide (NO), a potent vasodilator produced by endothelial cells, is thought to be the endothelium-dependent relaxing factor (EDRF) which mediates vascular relaxation in response to acetylcholine, bradykinin and substance P in many vascular beds. NO has been implicated in the regulation of blood pressure and regional blood flow, and also affects vascular smooth-muscle proliferation and inhibits platelet...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arginine
Share to Blood Pressure
Share to Endothelium, Vascular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Homeostasis

Share to Hypertension

Share to In Vitro Techniques

Share to Mutation

Source

Identifiers

PMID: 7545787
DOI: 10.1038/377239a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypertension in mice lacking the gene for endothelial nitric oxide synthase.PMID 7545787Read ↗

Elevated blood pressures in mice lacking endothelial nitric oxide synthase.Semantic proximity Read ↗

Generation of a conditional allele for the mouse endothelial nitric oxide synthase gene.Semantic proximity Read ↗

Investigation of vascular responses in endothelial nitric oxide synthase/cyclooxygenase-1 double-knockout mice: key role for endothelium-derived hyperpolarizing factor in the regulation of blood pressure in vivo.Semantic proximity Read ↗

Hypotension and reduced nitric oxide-elicited vasorelaxation in transgenic mice overexpressing endothelial nitric oxide synthase.Semantic proximity Read ↗

Endothelial dysfunction and elevated blood pressure in MAS gene-deleted mice.Semantic proximity Read ↗

Angiotensinergic stimulation of vascular endothelium in mice causes hypotension, bradycardia, and attenuated angiotensin response.Semantic proximity Read ↗

Arginase II knockout mouse displays a hypertensive phenotype despite a decreased vasoconstrictory profile.Semantic proximity Read ↗

Disruption of Physiological Balance Between Nitric Oxide and Endothelium-Dependent Hyperpolarization Impairs Cardiovascular Homeostasis in Mice.Semantic proximity Read ↗

Selective impairment of blood pressure reduction by endothelial nitric oxide synthase dimer destabilization in mice.Semantic proximity Read ↗

Structure of cerebral arterioles in mice deficient in expression of the gene for endothelial nitric oxide synthase.Semantic proximity Read ↗

Low blood pressure in endothelial cell-specific endothelin 1 knockout mice.Semantic proximity Read ↗

Role of nNOS in blood pressure regulation in eNOS null mutant mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.