Article
Endothelial dysfunction and elevated blood pressure in MAS gene-deleted mice.
Hypertension (Dallas, Tex. : 1979) - 1 Feb 2008
Xu Ping, Costa-Goncalves Andrey C, Todiras Mihail, Rabelo Luiza A, Sampaio Walkyria O, Moura Marina M, Santos Sergio Sousa, Luft Friedrich C, Bader Michael, Gross Volkmar, Alenina Natalia, Santos Robson A S
Abstract excerpt
Mas codes for a G protein-coupled receptor that is implicated in angiotensin-(1-7) signaling. We studied the cardiovascular phenotype of Mas-deficient mice backcrossed onto the FVB/N genetic background using telemetry and found that they exhibit higher blood pressures compared with controls. These Mas(-/-) mice also had impaired endothelial function, decreased NO production, and lower endothelial NO synthase...
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