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Article

Disruption of Physiological Balance Between Nitric Oxide and Endothelium-Dependent Hyperpolarization Impairs Cardiovascular Homeostasis in Mice.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2016

Godo Shigeo, Sawada Ayuko, Saito Hiroki, Ikeda Shohei, Enkhjargal Budbazar, Suzuki Kota, Tanaka Shuhei, Shimokawa Hiroaki

Abstract excerpt

OBJECTIVE: Endothelium-derived nitric oxide (NO) and endothelium-dependent hyperpolarization (EDH) play important roles in modulating vascular tone in a distinct vessel size-dependent manner; NO plays a dominant role in conduit arteries and EDH in resistance vessels. We have recently demonstrated that endothelial NO synthase (eNOS) is functionally suppressed in resistance vessels through caveolin-1...

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PMID: 26543099
DOI: 10.1161/ATVBAHA.115.306499

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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