Article
Angiotensinergic stimulation of vascular endothelium in mice causes hypotension, bradycardia, and attenuated angiotensin response.
Proceedings of the National Academy of Sciences of the United States of America - 12 Dec 2006
Ramchandran Ramaswamy, Takezako Takanobu, Saad Yasser, Stull Linda, Fink Bruno, Yamada Hirotsugu, Dikalov Sergey, Harrison David G, Moravec Christine, Karnik Sadashiva S
Abstract excerpt
It is not clear whether endothelial cell (EC) activation by the hormone angiotensin II (Ang II) modulates contraction of vascular smooth muscle cells (VSMCs) in the vasculature and whether impairment of this regulation in vivo contributes to hypertension. Delineation of the actions of Ang II through the type 1 receptor (AT1R) on ECs in the blood vessels has been a challenging problem because of the predominance...
Topics
- Angiotensins
- Animals
- Blood Pressure
- Bradycardia
- Endothelium, Vascular
- Gene Expression
- Hypotension
- Mice
- Mice, Transgenic
- Nitric Oxide