Article
Low blood pressure in endothelial cell-specific endothelin 1 knockout mice.
Hypertension (Dallas, Tex. : 1979) - 1 Jul 2010
Kisanuki Yaz Y, Emoto Noriaki, Ohuchi Takashi, Widyantoro Bambang, Yagi Keiko, Nakayama Kazuhiko, Kedzierski Rafal M, Hammer Robert E, Yanagisawa Hiromi, Williams S Clay, Richardson James A, Suzuki Takashi, Yanagisawa Masashi
Abstract excerpt
Endothelin (ET) 1 is a potent vasoconstrictor peptide produced by vascular endothelial cells and implicated in various pathophysiologic states involving abnormal vascular tone. Homozygous ET-1 null mice have craniofacial and cardiac malformations that lead to neonatal death. To study the role of ET-1 in adult vascular physiology, we generated a mouse strain (ET-1(flox/flox);Tie2-Cre mice) in which ET-1 is...
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