Article
Generation of a conditional allele for the mouse endothelial nitric oxide synthase gene.
Genesis (New York, N.Y. : 2000) - 1 Sept 2012
Jiang Rosie, Wang Suwan, Takahashi Keiko, Fujita Hiroki, Fruci Christopher R, Breyer Matthew D, Harris Raymond C, Takahashi Takamune
Abstract excerpt
Mice with endothelial nitric oxide synthase (eNOS) deletions have defined the crucial role of eNOS in vascular development, homeostasis, and pathology. However, cell specific eNOS function has not been determined, although an important role of eNOS has been suggested in multiple cell types. Here, we have generated a floxed eNOS allele in which exons 9-12, encoding the sites essential to eNOS activity, are flanked...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.