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Article

Role of nNOS in blood pressure regulation in eNOS null mutant mice.

Hypertension (Dallas, Tex. : 1979) - 1 Nov 1998

Kurihara N, Alfie M E, Sigmon D H, Rhaleb N E, Shesely E G, Carretero O A

Abstract excerpt

The role of neural nitric oxide synthase (nNOS) in regulating blood pressure (BP) remains uncertain. Recently it was reported that in mice lacking functional endothelial NOS (eNOS) genes (-/-), acute administration of a nonselective NOS inhibitor, Nw-nitro-L-arginine, decreased mean BP, suggesting that NO released by non-eNOS isoforms increases BP. Because the inducible NOS isoform is not constitutively expressed...

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Identifiers

PMID: 9822444
DOI: 10.1161/01.hyp.32.5.856

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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