Selective impairment of blood pressure reduction by endothelial nitric oxide synthase dimer destabilization in mice.

doi:10.1097/HJH.0000000000001127

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Article

Selective impairment of blood pressure reduction by endothelial nitric oxide synthase dimer destabilization in mice.

Journal of hypertension - 1 Jan 2017

Suvorava Tatsiana, Pick Stephanie, Kojda Georg

Abstract excerpt

OBJECTIVES: Endothelial dysfunction and oxidative stress are associated with hypertension but whether endothelial superoxide may play a role in the early development of essential hypertension remains uncertain. We investigated whether endothelial nitric oxide synthase (eNOS)-derived endothelial oxidative stress is involved in the regulation of SBP. METHODS: Wild-type eNOS [mice with endothelium-specific...

Topics

Animals
Blood Pressure
Cattle
Mice
Mice, Inbred C57BL
Mutation
Nitric Oxide Synthase Type III
Oxidative Stress
Phosphorylation
Protein Stability

Source

Open in PubMed

Identifiers

PMID: 27861245
DOI: 10.1097/HJH.0000000000001127

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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