Article
Structure of cerebral arterioles in mice deficient in expression of the gene for endothelial nitric oxide synthase.
Circulation research - 15 Oct 2004
Baumbach Gary L, Sigmund Curt D, Faraci Frank M
Abstract excerpt
We examined effects of pharmacological inhibition of nitric oxide synthase (NOS) and genetic deficiency of the endothelial isoform of NOS (eNOS) on structure and mechanics of cerebral arterioles. We measured pressure, diameter, and cross-sectional area (CSA) of the vessel wall (histologically) in maximally dilated cerebral arterioles in mice that were untreated or treated for 3 months with the NOS inhibitor,...
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