Article
Heritable formation of neuroectodermal tumor in transgenic mice carrying the combined E1 region gene of adenovirus type 12 with the deregulated human renin promoter.
Journal of cellular biochemistry - 1 Apr 1995
Sugiyama F, Sagara M, Matsuda Y, Horiguchi H, Kamma H, Ogata T, Hatae T, Yagami K, Murakami K, Fukamizu A
Abstract excerpt
Adenovirus early 1 (E1) region gene products, including E1A and E1B, are required for transcriptional regulation of viral and cellular promoters in infected and transfected culture cells and for transformation of primary rodent cells. Here, we established a line of transgenic mice carrying the E1 region gene of human adenovirus type 12 under the control of the human renin promoter, in which a neuroectodermal...
Topics
- Adenovirus E1 Proteins
- Adenoviruses, Human
- Animals
- Cell Adhesion Molecules, Neuronal
- Cell Transformation, Neoplastic
- Female
- Genes, Regulator
- Genes, myc
- Genetic Markers
- Humans