Article
Transcriptional regulation of neu by RB and E1A in rat-1 cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Apr 1994
Yu D, Matin A, Hinds P W, Hung M C
Abstract excerpt
Functional inactivation of the tumor-suppressing retinoblastoma gene (Rb) is involved in the etiology of many types of human cancers, including hereditary retinoblastomas. The neu gene is a dominant transforming oncogene, and we previously found that the Rb-encoded protein (RB) suppresses neu-ind...
Topics
- Adenoviridae
- Animals
- Cell Line
- Cell Transformation, Neoplastic
- Cells, Cultured
- Genes, Retinoblastoma
- Mutation
- Transcription, Genetic