Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeted oncogenesis reveals a distinct tissue-specific utilization of alternative promoters of the human mineralocorticoid receptor gene in transgenic mice.

The Journal of biological chemistry - 17 Mar 2000

Le Menuet D, Viengchareun S, Penfornis P, Walker F, Zennaro M C, Lombès M

Abstract excerpt

The human mineralocorticoid receptor (hMR) is a nuclear receptor mediating aldosterone action, whose expression is driven by two alternative promoters, P1 and P2, flanking the two first 5'-untranslated exons. In vivo characterization of hMR regulatory regions was performed by targeted oncogenesis in mice using P1 or P2 directing expression of the large T antigen of SV40 (TAg). While transgenic P1.TAg founders...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue, Brown
Share to Antigens, Viral, Tumor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Leiomyosarcoma

Share to Lipoma

Share to Mineralocorticoids

Share to Receptors, Mineralocorticoid

Share to Simian virus 40

Share to Tissue Distribution

Source

Identifiers

PMID: 10713103
DOI: 10.1074/jbc.275.11.7878

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeted oncogenesis reveals a distinct tissue-specific utilization of alternative promoters of the human mineralocorticoid receptor gene in transgenic mice.PMID 10713103Read ↗

Characterization of the human mineralocorticoid receptor gene 5'-regulatory region: evidence for differential hormonal regulation of two alternative promoters via nonclassical mechanisms.Semantic proximity Read ↗

The Mineralocorticoid Receptor: Insights into its Molecular and (Patho)Physiological BiologySemantic proximity Read ↗

Expression and function of the human mineralocorticoid receptor: lessons from transgenic mouse modelsSemantic proximity Read ↗

Human Mineralocorticoid Receptor Genomic Structure and Identification of Expressed IsoformsSemantic proximity Read ↗

Differential Regulation and Function of 5′-Untranslated GR-Exon 1 TranscriptsSemantic proximity Read ↗

Differential expression of the murine and rat renin genes in peripheral subcutaneous tissue.Semantic proximity Read ↗

Targeted skin overexpression of the mineralocorticoid receptor in mice causes epidermal atrophy, premature skin barrier formation, eye abnormalities, and alopecia.Semantic proximity Read ↗

Mineralocorticoid and glucocorticoid receptor cooperation drives advanced phenotypes in triple-negative breast cancer.Semantic proximity Read ↗

Tissue-Specific Expression of α and β Messenger Ribonucleic Acid Isoforms of the Human Mineralocorticoid Receptor in Normal and Pathological StatesSemantic proximity Read ↗

Human mineralocorticoid receptor A and B protein forms produced by alternative translation sites display different transcriptional activitiesSemantic proximity Read ↗

Variable transcriptional regulation of the human aldosterone synthase gene causes salt-dependent high blood pressure in transgenic mice.Semantic proximity Read ↗

Identification of three human renin mRNA isoforms from alternative tissue-specific transcriptional initiationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.