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Article

Identification of three human renin mRNA isoforms from alternative tissue-specific transcriptional initiation

29 Jun 2000

Abstract excerpt

We have reported that mice transgenic for 140- and 160-kb P1 phage artificial chromosomes (PACs) containing the human renin gene express the gene in a highly tissue-restricted and regulated manner. Herein, we demonstrate that the transgene is also expressed appropriately throughout development. In the course of this investigation, we identified the existence of three transcriptional isoforms of human renin mRNA...

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PMID: 11015597
DOI: 10.1152/physiolgenomics.2000.3.1.25

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