Article
A new approach to the molecular basis of neoplastic transformation in the brain.
Neuropathology and applied neurobiology - 1 Oct 1992
Wiestler O D, Brüstle O, Eibl R H, Radner H, Von Deimling A, Plate K, Aguzzi A, Kleihues P
Abstract excerpt
Gene transfer into living organisms has evolved as a powerful approach to study in vivo effects of specific genes and to devise animal models of hereditary disorders. We have been particularly interested in an approach to introducing transforming genes into the nervous system. Since specific promoter sequences for targeting the expression of a transgene to many cell types of the brain are not yet isolated, a...
Topics
- Animals
- Brain Tissue Transplantation
- Cell Transformation, Neoplastic
- Endothelium, Vascular
- Fetal Tissue Transplantation
- Genes, Viral
- Humans
- Nervous System Neoplasms
- Oncogenes
- Phenotype
- Retroviridae