Article
HIV-1 RNA serum-load and resistant viral genotypes during early zidovudine therapy.
Lancet (London, England) - 1 Apr 1995
Loveday C, Kaye S, Tenant-Flowers M, Semple M, Ayliffe U, Weller I V, Tedder R S
Abstract excerpt
The response of HIV-1 to initial zidovudine (ZDV) treatment was assessed in 11 patients with severe HIV disease. We quantified serum HIV-1 concentrations and mutations associated with ZDV resistance by culture-independent methods. There was a prompt fall in serum HIV-1 RNA within 1-2 days of treatment with maximum suppression by seven days, which was paralleled by changes in serum p24 antigen (p24 Ag). Serum RNA...
Topics
- Adult
- Drug Resistance, Microbial
- Genotype
- HIV Core Protein p24
- HIV Infections
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Male
- Middle Aged
- Mutation
- RNA, Viral