Article
Host-parasite dynamics and outgrowth of virus containing a single K70R amino acid change in reverse transcriptase are responsible for the loss of human immunodeficiency virus type 1 RNA load suppression by zidovudine.
Proceedings of the National Academy of Sciences of the United States of America - 28 May 1996
de Jong M D, Veenstra J, Stilianakis N I, Schuurman R, Lange J M, de Boer R J, Boucher C A
Abstract excerpt
The association between human immunodeficiency virus type I (HIV-1) RNA load changes and the emergence of resistant virus variants was investigated in 24 HIV-1-infected asymptomatic persons during 2 years of treatment with zidovudine by sequentially measuring serum HIV-1 RNA load and the relative...
Topics
- Base Sequence
- CD4 Lymphocyte Count
- DNA Primers
- Genetic Variation
- HIV Reverse Transcriptase
- HIV Seropositivity
- HIV-1
- Homosexuality, Male
- Host-Parasite Interactions
- Humans
- Male
- Molecular Sequence Data
- Point Mutation