Article
Analysis of HIV-1 reverse transcriptase gene mutations in infected children treated with zidovudine.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association - 1 Nov 1998
Orlandi P, Cancrini C, Scaccia S, Romiti M L, Livadiotti S, Gattinara G C, Angelini F, Cox S, Rossi P
Abstract excerpt
Prolonged treatment with antiretroviral agents directed against reverse transcription (RT) in patients with HIV-1 infection results in the emergence of virus variants with reduced sensitivity containing mutations in the HIV-1 RT gene. Development of zidovudine (ZDV)-related mutations was studied...
Topics
- Anti-HIV Agents
- Child
- Child, Preschool
- Codon
- Cohort Studies
- Disease Progression
- Female
- Genetic Variation
- HIV Infections
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Infant
- Male
- Mutation