Article
Effect of zidovudine resistance mutations on virologic response to treatment with zidovudine-lamivudine-ritonavir: genotypic analysis of human immunodeficiency virus type 1 isolates from AIDS clinical trials group protocol 315.ACTG Protocol 315 Team.
The Journal of infectious diseases - 1 Feb 2000
Kuritzkes D R, Sevin A, Young B, Bakhtiari M, Wu H, St Clair M, Connick E, Landay A, Spritzler J, Kessler H, Lederman M M
Abstract excerpt
The effect of baseline drug resistance mutations on response to zidovudine, lamivudine, and ritonavir was evaluated in zidovudine-experienced persons infected with human immunodeficiency virus type 1 (HIV-1). Presence of the K70R mutation was associated with significantly higher plasma HIV-1 RNA levels at baseline. However, presence of resistance mutations did not affect the increase in plasma HIV-1 RNA during a...
Topics
- Adult
- Anti-HIV Agents
- Drug Resistance, Microbial
- Drug Therapy, Combination
- Female
- HIV Infections
- HIV Protease
- HIV Protease Inhibitors
- HIV Reverse Transcriptase