Article
Evolution of zidovudine resistance-associated genotypes in human immunodeficiency virus type 1-infected patients.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association - 1 May 1996
Cleland A, Watson H G, Robertson P, Ludlam C A, Brown A J
Abstract excerpt
Substantial differences have been described in the response of individual patients to zidovudine (ZDV) therapy, both in the clinical impact and in virus load. Genotypic changes associated with the appearance of drug resistance may also be different or occur at different rates. We have obtained th...
Topics
- Amino Acid Sequence
- Antiviral Agents
- Base Sequence
- CD4 Lymphocyte Count
- DNA Primers
- Drug Resistance, Microbial
- Evolution, Molecular
- Genes, pol
- Genome, Viral
- Genotype
- HIV Infections
- HIV-1
- Humans
- Leukocytes, Mononuclear
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Proviruses