Article
Evolution of zidovudine resistance-associated genotypes in human immunodeficiency virus type 1-infected patients.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association - 1 May 1996
Cleland A, Watson H G, Robertson P, Ludlam C A, Brown A J
Abstract excerpt
Substantial differences have been described in the response of individual patients to zidovudine (ZDV) therapy, both in the clinical impact and in virus load. Genotypic changes associated with the appearance of drug resistance may also be different or occur at different rates. We have obtained the nucleotide sequence of the RT domain of individual HIV-1 genomes extracted from 10 plasma and peripheral blood...
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