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Article

Interactions between stem cell factor and c-Kit are required for intestinal immune system homeostasis.

Immunity - 1 Dec 1994

Puddington L, Olson S, Lefrançois L

Abstract excerpt

Interactions between stem cell factor (SCF) and its receptor, c-Kit, are important for development of hematopoietic, melanocytes, and germ cells. T lymphocytes appeared normal in c-Kit (W/Wv) or SCF (SI/SId) mutant mice, except for those residing within the intestinal epithelium, the intraepithelial lymphocytes (IEL). Normally, IEL are composed of equal numbers of cells with alpha beta or gamma delta T cell...

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Identifiers

PMID: 7534619
DOI: 10.1016/s1074-7613(94)80015-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Interactions between stem cell factor and c-Kit are required for intestinal immune system homeostasis.PMID 7534619Read ↗

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Gut cryptopatches: direct evidence of extrathymic anatomical sites for intestinal T lymphopoiesis.Semantic proximity Read ↗

Zinc-finger transcription factor Slug contributes to the function of the stem cell factor c-kit signaling pathway.Semantic proximity Read ↗

The rat c-kit ligand, stem cell factor, induces the development of connective tissue-type and mucosal mast cells in vivo. Analysis by anatomical distribution, histochemistry, and protease phenotype.Semantic proximity Read ↗

Cytolytic and IFN-gamma-producing activities of gamma delta T cells in the mouse intestinal epithelium are T cell receptor-beta-chain dependent.Semantic proximity Read ↗

W(sh)/W(sh) c-Kit mutant mice possess interstitial cells of Cajal in the deep muscular plexus layer of the small intestine.Semantic proximity Read ↗

Stem cell factor is encoded at the Sl locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor.Semantic proximity Read ↗

Analyzing mast cell development and function using mice carrying mutations at W/c-kit or Sl/MGF (SCF) loci.Semantic proximity Read ↗

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