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Article

Mouse hematopoietic stem cells and the interaction of c-kit receptor and steel factor.

International journal of cell cloning - 1 Sept 1991

Ikuta K, Ingolia D E, Friedman J, Heimfeld S, Weissman I L

Abstract excerpt

Hematopoietic stem cells (HSCs) are distinguished from other hematopoietic progenitors in bone marrow by their unique ability to undergo multilineage differentiation and self-renewal. Two mouse mutations, dominant spotting (W) and steel (Sl), have pleiotropic effects on hematopoiesis, gametogenesis, and melanoblast development. These two mutations have been shown to be intrinsic (W) and microenvironmental (Sl)...

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Source

Identifiers

PMID: 1720154
DOI: 10.1002/stem.1991.5530090503

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mouse hematopoietic stem cells and the interaction of c-kit receptor and steel factor.PMID 1720154Read ↗

The kit ligand encoded at the murine Steel locus: a pleiotropic growth and differentiation factor.Semantic proximity Read ↗

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The murine W/c-kit and Steel loci and the control of hematopoiesis.Semantic proximity Read ↗

The biology of stem cell factor, a new hematopoietic growth factor involved in stem cell regulation.Semantic proximity Read ↗

The kit-ligand (steel factor) and its receptor c-kit/W: pleiotropic roles in gametogenesis and melanogenesis.Semantic proximity Read ↗

Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a number of steel alleles.Semantic proximity Read ↗

Stem cell factor and c-kit in the mammalian testis: lessons originating from Mother Nature's gene knockoutsSemantic proximity Read ↗

Role of c-kit receptor tyrosine kinase in the development, survival and neoplastic transformation of mast cells.Semantic proximity Read ↗

The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus.Semantic proximity Read ↗

Steel factor responsiveness regulates the high self-renewal phenotype of fetal hematopoietic stem cells.Semantic proximity Read ↗

The mouse W/c-kit locus. A mammalian gene that controls the development of three distinct cell lineages.Semantic proximity Read ↗

Stem cell factor is encoded at the Sl locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor.Semantic proximity Read ↗

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