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Article

Zinc-finger transcription factor Slug contributes to the function of the stem cell factor c-kit signaling pathway.

Blood - 15 Aug 2002

Pérez-Losada Jesus, Sánchez-Martín Manuel, Rodríguez-García Arancha, Sánchez Maria Luz, Orfao Alberto, Flores Teresa, Sánchez-García Isidro

Abstract excerpt

The stem cell factor c-kit signaling pathway (SCF/c-kit) has been previously implicated in normal hematopoiesis, melanogenesis, and gametogenesis through the formation and migration of c-kit(+) cells. These biologic functions are also determinants in epithelial-mesenchymal transitions during embryonic development governed by the Snail family of transcription factors. Here we show that the activation of c-kit by...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 12149208

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Zinc-finger transcription factor Slug contributes to the function of the stem cell factor c-kit signaling pathway.PMID 12149208Read ↗

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SLUG: Critical regulator of epithelial cell identity in breast development and cancerSemantic proximity Read ↗

The Slug gene is not essential for mesoderm or neural crest development in mice.Semantic proximity Read ↗

Slug regulates the Dll4-Notch-VEGFR2 axis to control endothelial cell activation and angiogenesisSemantic proximity Read ↗

The SCF/c-KIT system in the male: Survival strategies in fertility and cancerSemantic proximity Read ↗

Angiogenic sprouting is regulated by endothelial cell expression of Slug (Snai2)Semantic proximity Read ↗

Angiogenic sprouting is regulated by endothelial cell expression of SlugSemantic proximity Read ↗

Zinc-finger transcription factor slug contributes to the survival advantage of chronic myeloid leukemia cellsSemantic proximity Read ↗

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Stem cell factor is encoded at the Sl locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor.Semantic proximity Read ↗

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