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Article

Analyzing mast cell development and function using mice carrying mutations at W/c-kit or Sl/MGF (SCF) loci.

Annals of the New York Academy of Sciences - 1 Jan 1992

Galli S J, Tsai M, Gordon J R, Geissler E N, Wershil B K

Abstract excerpt

Mast cells have been implicated in a wide variety of biological responses, but identifying the nature and importance of the mast cell's specific contributions to these reactions has been difficult. W/Wv mice have mutations affecting the c-kit tyrosine kinase receptor which is encoded at the W locus and which is necessary for normal mast cell development. In W/Wv mice, the cells which ordinarily give rise to...

Topics

Animals
Chromosome Mapping
Hematopoietic Cell Growth Factors
Immunoglobulin E
Inflammation
Leukocytes
Mast Cells
Mice
Mutation
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-kit

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Skin

Stem Cell Factor

Substance P

Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 1280935
DOI: 10.1111/j.1749-6632.1992.tb39750.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1280935-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Analyzing mast cell development and function using mice carrying mutations at W/c-kit or Sl/MGF (SCF) loci.PMID 1280935Read ↗

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