Article
W(sh)/W(sh) c-Kit mutant mice possess interstitial cells of Cajal in the deep muscular plexus layer of the small intestine.
Neuroscience letters - 14 Aug 2009
Iino Satoshi, Horiguchi Kazuhide, Nojyo Yoshiaki
Abstract excerpt
The c-Kit receptor tyrosine kinase regulates the development and differentiation of various progenitor cells. W mutant mice with spontaneous mutations in the c-kit gene show various phenotypes such as anemia, infertility, loss of coat color and mast cells. c-Kit also regulates the development of the interstitial cells of Cajal (ICC) that are responsible for the motility regulation of the gastrointestinal...
Topics
- Animals
- Caveolae
- Electrical Synapses
- Immunohistochemistry
- Intestine, Small
- Mice
- Mice, Inbred BALB C
- Mice, Mutant Strains
- Microscopy, Electron
- Mitochondria
- Muscle, Smooth