Article
Interleukin-7 administration alters intestinal intraepithelial lymphocyte phenotype and function in vivo.
Cytokine - 21 Sept 2005
Yang Hua, Spencer Ariel U, Teitelbaum Daniel H
Abstract excerpt
BACKGROUND: Interleukin-7 (IL-7) plays a crucial role in controlling T-cell development and homeostasis. IL-7 knock out and IL-7 receptor knock out mice show distinct declines in absolute numbers of the intestinal intraepithelial lymphocytes (IEL). Therefore, we hypothesized that exogenous administration of IL-7 would alter IEL phenotype and function. METHODS: Adult C57BL/6J mice were treated with IL-7 or saline....
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