Article
Stem cell factor is encoded at the Sl locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor.
Cell - 5 Oct 1990
Zsebo K M, Williams D A, Geissler E N, Broudy V C, Martin F H, Atkins H L, Hsu R Y, Birkett N C, Okino K H, Murdock D C
Abstract excerpt
We have cloned a partial cDNA encoding murine stem cell factor (SCF) and show that the gene is syntenic with the Sl locus on mouse chromosome 10. Using retroviral vectors to immortalize fetal liver stromal cell lines from mice harboring lethal mutations at the Sl locus (Sl/Sl), we have shown that SCF genomic sequences are deleted in these lines. Furthermore, two other mutations at Sl, Sld and Sl12H, are...
Topics
- Amino Acid Sequence
- Anemia, Macrocytic
- Animals
- Base Sequence
- Cell Line
- Chromosome Mapping
- Cloning, Molecular
- Cricetinae
- DNA
- Genes
- Hematopoietic Cell Growth Factors